In the present work, our objective is to take advantage of the property presented by Ionic Liquids (ILs) based on 1-alkyl-3-methylimidazolium cations by having amphiphilic character when the alkyl group is a long hydrocarbon chain. These ILs can act as surfactants forming micelles in aqueous solution. In this sense, the micellar effect on a Diels-Alder reaction (DA) was analyzed taken as a reference. The reactive system studied consists of maleic anhydride and isoprene, variables such as diene:dienophile ratio and reaction temperatura among the most important were optimized. N, N-dodecylmethylimidazolium bromide was used at the critical micellar concentration (CMC) of 1 x 10^-2 M.

These “new systems” microheterogeneous would allow, in addition to better solubilization of non-polar substrates, to adopt milder reaction conditions.

The isolation of water-soluble polysaccharides and proteins solubilized during the treatment of rye flour in an isotonic aqueous medium is described. Protein and polysaccharide assays of the aqueous fractions showed the high extraction performance of these compounds. Then, nanoparticles were synthesized from these hydrophilic isolates using fluorescein as a model drug and sodium hexapolyphosphate as a cross-linker. The preparation process consisted of dispersion, desolvation, drug incorporation, crosslinking and separation of nanoparticles. The physicochemical analysis revealed that nanoparticles were successfully synthesized with rye hydrophilic isolates using a desolvation method. These studies demonstrated that rye nanoparticles are a promising candidate as an active compounds vehicle system.

Abstract:A series of 15 novel derivatives of Synthesis of 2, 4-substituted 1, 5- benzothiazepine 5a–l were synthesized in good yield from the key compound 1, 3-substituted-prop-2-en-1-one (3a-l), called chalcone, with 2-aminothiophenol (0.01mol) and pinch of zirconium oxychloride and solvent dimethyl formamide (DMF), by using ultra-sonication as one of the green chemistry tools. All the synthesised compounds were evaluated for anticonvulsant activity. The synthesized derivatives were investigated for CNS depressant, maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (sc-PTZ) induced seizure and neurotoxicity screening.

Metal-organic frameworks (MOFs) are a group of high-porosity materials that had been studying for enormous applications. Today, with increasing the human population and the growth of technology and industry, the entry of various chemical and microbial contaminants such as toxic substances, heavy metals and hospital wastewater into the ecosystem creates new health problems and important health hazards for human and other creatures.[1]

Several methods have been used to remove heavy metals from water, including ion exchange, membrane filtration, chemical deposition, and adsorption in the past two decades. Due to the effectiveness, economic value, flexibility of design and reversibility, absorption techniques are currently one of the technologies used to remove heavy metals. According to the literature, one of the most important features of a good absorbent is its selectivity. Many factors such as electrostatic interactions, covalent interactions, pore size and shape can affect the absorption selectivity.[2]

In order to achieve the purpose of designing MOFs with the ability to absorb metallic contaminants, a metal-organic framework with the formula of [CoNi(µ₃-tp)₂(µ₂-pyz)₂[ containing nickel and cobalt ions and two types of ligands including terephthalic acid (H₂tp) and pyrazine (pyz) was prepared.

In this paper, the adsorption behavior of the named framework was investigated for removal of heavy metal ions and, according to ICP data, it was shown that the Cr ions, as a serious metallic pollutant have a high uptake.

Starting from methyl-1,4-Dioxo-3-phenyl-3,4-dihydro-1H-phthalazin-2-yl-acetate (2) eighteen newly Phthalazine dione derivatives were synthesized. The starting material 2 was prepared by N-alkylation of 2-phenyl-2,3-dihydrophthalazine-1,4-dione (1) with ethyl chloro acetate under reflux over night. 2-(1,4-dioxo-3-phenyl-3,4-dihydrophthalazin-2(1H)-yl)acetohydrazide (3) was prepared by hydrazinolysis of ester 2 with hydrazine hydrate under reflux. Monopeptide 4a-c were prepared via azide coupling method by coupling of hydrazide 3 with different methyl ester of glycine, β-alanine and L-leucine respectively. The hydrazides 5a-c were prepared by hydrazinolysis of esters 4a-c with hydrazine hydrate respectively. Similarly; dipeptides 6a-i were prepared form coupling of methyl esters of glycine, β-alanine and L-leucine with hydrazides 5a-c via azide coupling method. Schiff’s base hydrazones 7a-i were prepared by condensation of hydrazides 5a-c with different aldehydes such as 4-chlorobenzaldehyde, 4-methoxybenzaldehyde and 4-nitrobenzaldehyde.

The anti-bacterial activities of the synthesized compound were screened in vitro against E.coli, Salmonella and Staphylococcus aureus with comparison to 2-phenyl-2,3-dihydrophthalazine-1,4-dione (1). The results showed that most compounds have activities against E.coli and a little compounds were sensitive to Salmonella but there no significance response to Staphylococcus aureus. Also the anti-cancer activities were assayed and some synthesized phthalazinedione has high activity in inhibition of HEPG2 and MCF-7 cancer cell lines.